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The UHNMAC is interested in participating in collaborative research projects with academic and commercial researchers. We are able to contribute valuable array expertise to a project, as well as extensive bioinformatics support. We believe that establishing collaborations will increase the research knowledge base at the UHN.

Please note that for standard microarray services, collaborators most often pay for the microarray services provided, including the cost of the arrays, associated reagents, and data analysis. If the collaboration involves the development of a novel technique, the experimental costs may be subsidised.

If you would like more information regarding a collaborative project with us, please contact Neil Winegarden at

past collaborations

I have been working with the Microarray Centre for several years at multiple levels: initially, as a provider of cDNA arrays, then as a service entity to generate gene expression profiles, and more recently on a comprehensive level as a collaborator. My interactions with Neil Winegarden, the director of operations, Carl Virtanen, manager of bioinformatics, and Natalie Stickle, project manager have been very positive. Their expertise and professionalism are commendable and they have made important contributions toward our research goals.

~Ted Brown, PhD
University Head, Division of Reproductive Endocrinology and Infertility
Associate Professor, University of Toronto
Group Leader, Toronto Ovarian Cancer Research Network

Excellent group. I particularly value their interest in research and what they add to the research studies we are collaborating on. The Centre provides more than just the techniques. They also engaged in a lot of tweaking of the techniques to apply to the work we are doing.

~Ellen M Greenblatt, MD, FRCSC
Clinical Director, Reproductive Biology and IVF Units, Mount Sinai Hospital
Associate Professor, University of Toronto

The UHNMAC was an integral part of our most recent DNA methylation study - we used their Human 12K CpG island microarrays and collaborated with the bioinformatics team to analyze and visualize the methylation profiles. Carl's experience with a variety of software applications allows for quality custom data analysis and Carl, Neil, and Patrick's insightful discussions and recommendations were invaluable. This group is an ideal partner for array-based epigenetic research.

~Art Petronis, MD, PhD
Head & Senior Scientist, Krembil Family Epigenetics Laboratory
Centre for Addiction and Mental Health
Professor, University of Toronto

Publications from collaborations

Kaminsky ZA, Tang T, Wang S-C, et al. DNA methylation profiles in monozygotic and dizygotic twins. Nature Genetics 2009, 41:240-245

Muro EM, Herrington R, Janmohamed S, et al. Identification of gene 3' ends by automated EST cluster analysis. PNAS 2008, 105(51):20286

Tone AA, Begley H, Sharma M, et al. Gene expression profiles of luteal phase fallopian tubes epithelium from BRCA mutation carriers resemble high-grade serous carcinoma. Clin Cancer Res 2008 14(13):4067-78

Flanagan JM, Popendikyte V, Pozdniakovaite N, et al. Intra- and Interindividual Epigenetic Variation in Human Germ Cells. Am J Hum Genet, 2006, 79(1):67-84

Schumacher A, Kapranov P, Kaminsky Z, et al. Microarray-based DNA methylation profiling: technology and applications. Nuc. Acids Res. 2006, 34(2):528-542